| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHCHD6 | TMED4 | ENSP00000290913 | ENSP00000404042 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.645 |
| CHCHD6 | UBC | ENSP00000290913 | ENSP00000344818 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | ubiquitin C | 0.495 |
| CNIH4 | TMED10 | ENSP00000420443 | ENSP00000303145 | cornichon homolog 4 (Drosophila) | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.693 |
| CNIH4 | TMED2 | ENSP00000420443 | ENSP00000262225 | cornichon homolog 4 (Drosophila) | transmembrane emp24 domain trafficking protein 2; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the [...] | 0.536 |
| CNIH4 | TMED4 | ENSP00000420443 | ENSP00000404042 | cornichon homolog 4 (Drosophila) | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.563 |
| CNIH4 | UBC | ENSP00000420443 | ENSP00000344818 | cornichon homolog 4 (Drosophila) | ubiquitin C | 0.521 |
| IKBIP | TMED4 | ENSP00000299157 | ENSP00000404042 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |
| IKBIP | UBC | ENSP00000299157 | ENSP00000344818 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | ubiquitin C | 0.620 |
| PPIC | TMED10 | ENSP00000303057 | ENSP00000303145 | peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.482 |
| PPIC | TMED4 | ENSP00000303057 | ENSP00000404042 | peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |
| PPIC | UBC | ENSP00000303057 | ENSP00000344818 | peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) | ubiquitin C | 0.478 |
| SF1 | SRPRB | ENSP00000366604 | ENSP00000418401 | splicing factor 1 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | 0.644 |
| SF1 | TMED4 | ENSP00000366604 | ENSP00000404042 | splicing factor 1 | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |
| SF1 | UBC | ENSP00000366604 | ENSP00000344818 | splicing factor 1 | ubiquitin C | 0.896 |
| SLC25A3 | TMED4 | ENSP00000228318 | ENSP00000404042 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |
| SLC25A3 | UBC | ENSP00000228318 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | ubiquitin C | 0.976 |
| SRPRB | SF1 | ENSP00000418401 | ENSP00000366604 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | splicing factor 1 | 0.644 |
| SRPRB | TMED4 | ENSP00000418401 | ENSP00000404042 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |
| SRPRB | UBC | ENSP00000418401 | ENSP00000344818 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | ubiquitin C | 0.976 |
| TMED10 | CNIH4 | ENSP00000303145 | ENSP00000420443 | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | cornichon homolog 4 (Drosophila) | 0.693 |
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